3+ day, 13+ hour ago   (274+ words) COLORECTAL cancer research has identified a core transcriptional regulatory circuitry involving MYC, ETS2 and FOXP1 that controls cancer type specific super enhancer activity and supports expression of key genes. The study reported that the master transcription factor MYC actively regulated super enhancer…...

4+ day, 13+ hour ago   (507+ words) EARLIER use of sodium-glucose cotransporter-2 (SGLT-2) inhibitors following severe acute kidney injury (AKI) may be associated with better kidney outcomes in adults with Type 2 diabetes, new research suggests. Patients prescribed an SGLT-2 inhibitor within 30 days of leaving hospital had a…...

4+ day, 6+ hour ago   (350+ words) Ketty Peris | Chair; Full Professor of Dermatology, Department of Dermatology,Catholic University of the Sacred Heart, Rome, Italy The diagnosis of melanoma has evolved considerably in recent years, shifting from an approach based on clinical examination to an integrated diagnostic…...

4+ day, 13+ hour ago   (186+ words) The single-centre exploratory trial included 30 patients with stroke, who were randomly assigned to either an intervention group or a control group. Each group included 15 participants. Both groups demonstrated significant improvements in MMSE and MoCA scores. However, the researchers found no…...

4+ day, 13+ hour ago   (445+ words) DISTINCT changes in the lung microbiome and metabolism may be associated with progression from community-acquired pneumonia (CAP) to acute respiratory distress syndrome (ARDS) in children, according to new research. The study identified reduced microbial diversity and altered concentrations of dozens…...

5+ day, 13+ hour ago   (305+ words) EX VIVO cardiac simulators are emerging as a promising tool for personalised cardiovascular care, according to a new narrative review. These simulator platforms combine native cardiac tissue with mechanical circulatory systems to recreate physiologically relevant cardiac function and provide insights…...

5+ day, 13+ hour ago   (456+ words) RECEIVING immune checkpoint inhibitor therapy earlier in the day may be associated with substantially longer survival amongst patients with advanced cancer, according to new research. The large UK cohort study found that patients who received most of their immune checkpoint…...

6+ day, 3+ hour ago   (462+ words) EMJ This site is intended for healthcare professionals Alcohol and Gout Risk: How Beverage Choices Alter Flare-Ups - Heavy alcohol intake markedly elevates gout risk, with beer and spirits driving the greatest clinical danger. - Beverage types diverge: beer and spirits elevate…...

6+ day, 13+ hour ago   (445+ words) EARLY initiation of statin therapy following a diagnosis of Type 2 diabetes may be associated with a lower risk of developing dementia, according to new research. The nationwide Danish study found that starting statins within 1 year of Type 2 diabetes diagnosis was…...

6+ day, 13+ hour ago   (291+ words) DEXMEDETOMIDINE reduced epidural analgesic use after VATS lobectomy while improving early pain control and patient satisfaction. The prospective, randomized, double-blind study enrolled 68 patients undergoing elective video-assisted thoracoscopic (VATS) lobectomy. Of these, 61 were included in the final analysis, comprising 31 patients who…...